Mehrdad Nikfarjam Selected Research

p21-Activated Kinases

11/2023	PAK in Pancreatic Cancer-Associated Vasculature: Implications for Therapeutic Response.
11/2022	The trilogy of P21 activated kinase, autophagy and immune evasion in pancreatic ductal adenocarcinoma.
1/2019	Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer.
9/2018	p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation.
1/2018	Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine.
6/2017	Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.
1/2017	Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer.
1/2016	FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.
4/2015	The role of p21-activated kinases in pancreatic cancer.
5/2014	Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.

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Mehrdad Nikfarjam Research Topics

Disease

36	Neoplasms (Cancer) 11/2023 - 01/2004
21	Pancreatic Neoplasms (Pancreatic Cancer) 02/2023 - 05/2009
18	Neoplasm Metastasis (Metastasis) 06/2017 - 01/2004
10	Necrosis 05/2020 - 03/2005
6	Adenocarcinoma 02/2023 - 01/2019
6	Colorectal Neoplasms (Colorectal Cancer) 06/2017 - 03/2005
4	Pancreatic Fistula (Pancreatic Fistulas) 12/2022 - 01/2008
4	Wounds and Injuries (Trauma) 12/2018 - 09/2009
4	Hyperthermia 07/2005 - 01/2004
3	Hepatocellular Carcinoma (Hepatoma) 02/2023 - 11/2022
3	Reperfusion Injury 05/2020 - 08/2005
3	Margins of Excision 06/2016 - 07/2008
3	Acute Cholecystitis 12/2014 - 02/2013
3	Infections 07/2014 - 04/2009
2	End Stage Liver Disease 02/2023 - 01/2016
2	Carcinogenesis 11/2022 - 06/2017
2	Biliary Tract Neoplasms (Biliary Tract Cancer) 11/2019 - 01/2017
2	Liver Failure 06/2019 - 01/2018
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 07/2018 - 01/2015
2	Breast Neoplasms (Breast Cancer) 10/2013 - 08/2010
2	Hypoxia (Hypoxemia) 10/2013 - 11/2012
2	Surgical Wound Infection 08/2010 - 09/2009
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 11/2008 - 09/2008
2	Pancreatitis 11/2007 - 08/2007
2	Carcinoma (Carcinomatosis) 04/2007 - 04/2003
1	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 02/2023
1	Respiratory Insufficiency (Respiratory Failure) 01/2023
1	Acute Pain 01/2023
1	Postoperative Pain 01/2023
1	Hypoalbuminemia 01/2023
1	Melanoma (Melanoma, Malignant) 11/2022
1	Glioblastoma (Glioblastoma Multiforme) 11/2022
1	Anemia 01/2020
1	Colic (Abdominal Cramps) 12/2018
1	Cholelithiasis 12/2018

Drug/Important Bio-Agent (IBA)

10	p21-Activated KinasesIBA 11/2023 - 05/2014
8	Gemcitabine FDA Link 01/2023 - 05/2014
4	Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)IBA 01/2006 - 03/2005
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2013 - 04/2011
3	Oxi 4503IBA 10/2013 - 07/2008
3	CytokinesIBA 07/2010 - 08/2005
3	NAD (NADH)IBA 01/2006 - 06/2005
3	NeodymiumIBA 01/2006 - 03/2005
2	BilirubinIBA 01/2023 - 08/2011
2	C-Reactive ProteinIBA 01/2023 - 08/2011
2	Dronabinol (THC)FDA LinkGeneric 10/2020 - 01/2019
2	CannabinoidsIBA 10/2020 - 01/2019
2	glaucarubinoneIBA 12/2016 - 05/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2010 - 04/2009
2	MicellesIBA 08/2010 - 08/2007
2	pirarubicinIBA 08/2010 - 08/2007
2	Imatinib Mesylate (Gleevec)FDA Link 11/2008 - 09/2008
2	Oxygen (Dioxygen)IBA 08/2007 - 08/2007
2	yttrium-aluminum-garnetIBA 01/2006 - 03/2005
2	AluminumIBA 07/2005 - 06/2005
2	YttriumIBA 07/2005 - 06/2005
2	QuartzIBA 10/2004 - 01/2004
1	Sirolimus (Rapamycin)FDA Link 02/2023
1	AlbuminsIBA 01/2023
1	Opioid Analgesics (Opioids)IBA 01/2023
1	Clonidine (ST 155)FDA LinkGeneric 01/2023
1	Morphine (MS Contin)FDA LinkGeneric 01/2023
1	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 01/2023
1	folfirinoxIBA 10/2022
1	130-nm albumin-bound paclitaxelIBA 10/2022
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 11/2021
1	Human Serum Albumin FDA LinkGeneric 11/2021
1	CannabidiolIBA 10/2020
1	Phosphotransferases (Kinase)IBA 10/2020
1	ZincIBA 05/2020
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019
1	Indicators and Reagents (Reagents)IBA 01/2019
1	PF 3758309IBA 01/2019
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2019
1	CannabinolIBA 01/2019
1	LigandsIBA 01/2019

Therapy/Procedure

16	Therapeutics 10/2022 - 10/2004
11	Drug Therapy (Chemotherapy) 11/2023 - 11/2008
7	Lasers (Laser) 01/2006 - 01/2004
6	Hepatectomy 11/2022 - 09/2004
5	Pancreatectomy 11/2021 - 01/2008
5	Pancreaticoduodenectomy 01/2017 - 01/2008
4	Length of Stay 01/2023 - 09/2012
4	Laparoscopic Cholecystectomy 12/2018 - 10/2011
3	Liver Transplantation 02/2023 - 01/2016
3	Immunotherapy 11/2022 - 09/2018
3	Cholecystectomy 12/2018 - 12/2012
3	Laparotomy 02/2014 - 09/2009
3	Aftercare (After-Treatment) 10/2013 - 01/2004
3	Solid-State Lasers 06/2005 - 10/2004
2	Neoadjuvant Therapy 02/2023 - 07/2009
2	Radiofrequency Ablation 11/2022 - 06/2010
2	Laser Therapy (Surgery, Laser) 05/2011 - 01/2006
2	Colectomy 11/2009 - 05/2009
2	Hyperbaric Oxygenation 11/2007 - 08/2007
2	Induced Hyperthermia (Thermotherapy) 06/2005 - 10/2004
1	Analgesia 01/2023
1	Patient Readmission 01/2020
1	Blood Transfusion (Blood Transfusions) 01/2020
1	Radiotherapy 01/2020